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KMID : 0605720060120020153
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Journal of the Korean Society of Biological Therapies in Psychiatry
2006 Volume.12 No. 2 p.153 ~ p.161
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The Neural Correlates of Second Generation Antipsychotics Related to Food Craving in Schizophrenic Patients after Meal
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Jeong Bum-Seok
Lee Chang-Hwa
Hong Sung-Kyoon
Choi Jee-Wook
Kim Ji-Woong
Lee Sun-Woo
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Abstract
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Objectives: To explore the neural correlates of antipsychotics related food craving in schizophrenic patients
Methods：A T2*-weighted echoplanar imaging sequences obtained were used to collect 120 BOLD images during the passive seeing of food paradigm after meal. The food paradigm was consisted of three blocks of food pictures and three blocks of pictures of natural thing in both ten healthy volunteers and schizophrenic patients having second generation antipsychotics. The imaging data were investigated to find differences in the food cue and craving related network between healthy volunteers and schizophrenic patients after meal. The relationship between food cue or craving related neural activity and clinical variable was explored. Activation maps were acquired by means of the random effect model using SPM2.
Results：Less extensive food cue and craving related regions were activated in schizophrenic patients having second generation antipsychotics after meal. Neural activities of both hypothalamus and thalamus were correlated with the prescribed duration of current antipsychotics.
Conclusions：This study demonstrated that schizophrenic patients’ brain is less respond to food cue after meal even though they are having second generation antipsychotics. The decrease of hypothalamic activity could explain the plateau phenomenon or decrease of both food craving and body weight according to persistent second generation antipsychotic medication.
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KEYWORD
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Schizophrenia, Antipsychotics, Weight gain, Hypothalamus, Food craving, Functional neuroimaging
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